The ‘cord blood’ within umbilical cord that connects mother and fetus
Is the starting point of creation of all tissues of the fetus, and has active cell division
and immune system, Leading it to attract attention as a future new drug raw material.

The cord blood for the source of the conditioned media material is transformed into
an optimum stem cell for the production of protein growth factors through the process
of applying 3 patented technologies at the GMP certification facility.

• [Patent] No. 10-0950195 Patent on method for isolation of stem cell derived from umbilical cord blood
• [Patent] No. 10-1158664 Patent on expansion of conditioned media of umbilical cord blood-derived stem cells
• [Patent] No. 10-1627907 Patent on isolated umbilical cord blood-derived pluripotent stem cell

Through a thorough raw materialization processing, umbilical cord blood stem cell conditioned
media is produced to be containing abundant growth factors that are effective on skin.
The initial conditioned media is discarded, and through special cultural medium, the final
conditioned media with only growth factors which improve skin health is produced.
Moreover, after about 1 month of quality inspection under legal procedures,
it is transformed into final cosmetic raw material.

The conditioned media contains 89 active protein components including EGF
and GDF11 which are produced by umbilical cord blood stem cells.
89 effective protein ingredients promote the growth and regeneration of skin
constituents, helping to prevent skin aging and wrinkles.

GDF11, one of the 89 active proteins in conditioned media,
was noticed as a key to youth in the global scientific journal SCIENCE in 2014
‘Science, May 2014, “Restoring Systemic GDF11 Levels Reverses Age-Related Dysfunction in Mouse Skeletal Muscle”’
BBREP_2018_84_R1, Conditioned media from human umbilical cord blood-derived mesenchymal stem cells stimulate rejuvenation function in human skin

'EXOSOME' is an active substance carrier self-produced by umbilical cord blood stem cells
'EXOSOME' in the conditioned media allows 89 active protein ingredients to be absorbed into the skin without loss.
This action mechanism of 'EXOSOME' has been proved by an SCI-classed paper.

Biochemical and Biophysical Research Communications (2017) / Exosomes derived from
human umbilical cord blood mesenchymal stem cells stimulates rejuvenation of human skin

The conditioned media promotes the secretion of human epidermal fibroblast
collagen and elastin to help the skin restore its elasticity.

Korea Research Institute of Dermatological Sciences / 2016.10.05~2016.11.30
Effectiveness test of increase in the productivity of human epidermal fibroblast collagen by
'Human umbilical cord blood derived stem cell conditioned media (USC-CM™)＇

Through continuous research on GDF11 for skin aging prevention, we became the first company
in the industry to obtain a patent for a cosmetic raw material composition including GDF11

• [Patent] 10-1810385 Compositions comprising GD11 and their usages